Potential Roles of HLA-G and MDSCs in Virus Infection

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of granulocytic or monocytic cells that could inhibit both innate and adaptive immune response [1]. Suppressive factors expressed by MDSCs, such as arginase-1, reactive oxygen species, inducible nitric oxide synthase and program death ligand 1, play critical roles in inhibition of T cell, B cell and NK cell mediated immune responses, and in induction of tolerogenic Tregs and regulatory DCs [2]. Other than extensive investigations have been carried out for the suppressive function and clinical significance of MDSCs among cancer patients and animal tumor models, increasing findings have demonstrated its relevance to virus infection [3].